منابع مشابه
A model for inter-laminar shear stress in laminated composites
The paper presents an analytical model for the estimation of shear stress at the interface of adhesively bonded layers in laminated composites. For this purpose, a new shear stress function is proposed that accounts for the influence of shear lag in laminates assembled using adhesive layers of different types and thicknesses. In addition to the estimation of interfacial stress, the function can...
متن کاملMolecular mechanism of endothelial growth arrest by laminar shear stress.
This study was designed to elucidate the mechanism underlying the inhibition of endothelial cell growth by laminar shear stress. Tumor suppressor gene p53 was increased in bovine aortic endothelial cells subjected to 24 h of laminar shear stress at 3 dynes (1 dyne = 10 microN)/cm(2) or higher, but not at 1.5 dynes/cm(2). One of the mechanisms of the shear-induced increase in p53 is its stabiliz...
متن کاملLaminar shear stress and 3' polyadenylation of eNOS mRNA.
The 3' poly(A) tail is important in messenger RNA stability and translational efficiency. In somatic tissues, 3' polyadenylation of mRNAs has been thought to largely be a constitutively active process. We have reported that laminar shear stress causes a brief increase in endothelial nitric oxide synthase (eNOS) transcription, followed by a prolonged increase in eNOS mRNA stability. We sought to...
متن کاملLaminar shear stress inhibits cathepsin L activity in endothelial cells.
OBJECTIVE The cysteine proteases, cathepsins, have been implicated in vascular remodeling and atherosclerosis, processes known to be regulated by shear stress. It is not known, however, whether shear regulates cathepsins. We examined the hypothesis that shear stress regulates cathepsin activity in endothelial cells. METHODS AND RESULTS Mouse aortic endothelial cells (MAECs) exposed to atherop...
متن کاملLaminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells.
OBJECTIVE Laminar shear stress plays critical roles in vascular homeostasis and exerts various metabolic effects on endothelial cells (ECs). Stearoyl-CoA desaturase-1 (SCD1), which catalyzes the biosynthesis of monounsaturated fatty acids, affects the lipid composition and fluidity of the cell membrane. Thus, we examined the effect of laminar flow on SCD1 expression in ECs. METHODS A flow cha...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 1998
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.18.5.677